Prospective evaluation of the frequency and clinical significance of antineutrophil cytoplasmic and anticardiolipin antibodies in community cases of patients with rheumatoid arthritis
Identifieur interne : 002505 ( Main/Exploration ); précédent : 002504; suivant : 002506Prospective evaluation of the frequency and clinical significance of antineutrophil cytoplasmic and anticardiolipin antibodies in community cases of patients with rheumatoid arthritis
Auteurs : O. Vittecoq ; F. Jouen-Beades ; K. Krzanowska ; I. Bichon-Tauvel ; J. F. Menard [France] ; A. Daragon ; D. Gilbert ; F. Tron ; X. Le Loe TSource :
- Rheumatology [ 1462-0324 ] ; 2000.
Abstract
Objectives. To evaluate the frequencies of antineutrophil cytoplasmic (ANCA), anticardiolipin (aCLA) and anti‐β2‐glycoprotein 1 antibodies (aβ2‐GP1A) in rheumatoid arthritis (RA) of limited duration in patients recruited primarily from private practitioners (80%), and to attempt to correlate the presence of these antibodies with certain clinical and/or biological criteria. Patients and methods. Patients (n = 102) with RA evolving for <5 yr (mean 2.2 yr) were recruited. A home evaluation collected clinical data [Ritchie articular index, Health Assessment Questionnaire (HAQ) index, extra‐articular manifestations] and blood for biological analyses [C‐reactive protein (CRP), rheumatoid factor, ANCA, aCLA, aβ2‐GP1A]. ANCA were detected by indirect immunofluorescence on neutrophils and their specificity was determined by enzyme‐linked immunosorbent assay (ELISA) and confirmed by immunoblotting; aCLA and aβ2‐GP1A were detected by ELISA. Results. Patients had mild RA (Ritchie = 11/78 ± 9.6; HAQ = 0.79/3 ± 0.7), probably due to the recruitment procedure. ANCA, aCLA and aβ2‐GP1A frequencies were 18.5, 7 and 0%, respectively. Titres of ANCA and aCLA were low. A perinuclear ANCA staining pattern was exclusively observed and lactoferrin was shown to be the major antigen recognized. No relationship was found between ANCA and aCLA and/or rheumatoid factor, or any clinical manifestations. ANCA were more common in RA of longer duration (cut‐off: 4 yr; P = 0.05) and aCLA were correlated with the CRP level (P = 0.05). Conclusions. In RA of recent onset, ANCA and aCLA were detected at low titres and frequencies, and were not associated with any clinical manifestations. A longitudinal study is needed to determine whether their early appearance is predictive of subsequent disease severity.
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DOI: 10.1093/rheumatology/39.5.481
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Vittecoq</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Jouen Eades, F" sort="Jouen Eades, F" uniqKey="Jouen Eades F" first="F." last="Jouen-Beades">F. Jouen-Beades</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Krzanowska, K" sort="Krzanowska, K" uniqKey="Krzanowska K" first="K." last="Krzanowska">K. Krzanowska</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bichon Auvel, I" sort="Bichon Auvel, I" uniqKey="Bichon Auvel I" first="I." last="Bichon-Tauvel">I. Bichon-Tauvel</name><affiliation><wicri:noCountry code="no comma">Collège des Rhumatologues de Haute‐Normandie and</wicri:noCountry></affiliation></author><author><name sortKey="Menard, J F" sort="Menard, J F" uniqKey="Menard J" first="J. F." last="Menard">J. F. Menard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Biométrie‐Biostatistique, Centre Hospitalier Universitaire de Rouen, 76031 Rouen Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Daragon, A" sort="Daragon, A" uniqKey="Daragon A" first="A." last="Daragon">A. Daragon</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Gilbert, D" sort="Gilbert, D" uniqKey="Gilbert D" first="D." last="Gilbert">D. Gilbert</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Tron, F" sort="Tron, F" uniqKey="Tron F" first="F." last="Tron">F. Tron</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Le Loe T, X" sort="Le Loe T, X" uniqKey="Le Loe T X" first="X." last="Le Loe T">X. Le Loe T</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Rheumatology</title><title level="j" type="abbrev">Rheumatology</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><publisher>Oxford University Press</publisher><date when="2000-05">2000</date><biblScope unit="vol">39</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="481">481</biblScope><biblScope unit="page" to="489">489</biblScope></imprint><idno type="ISSN">1462-0324</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-0324</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives. To evaluate the frequencies of antineutrophil cytoplasmic (ANCA), anticardiolipin (aCLA) and anti‐β2‐glycoprotein 1 antibodies (aβ2‐GP1A) in rheumatoid arthritis (RA) of limited duration in patients recruited primarily from private practitioners (80%), and to attempt to correlate the presence of these antibodies with certain clinical and/or biological criteria. Patients and methods. Patients (n = 102) with RA evolving for <5 yr (mean 2.2 yr) were recruited. A home evaluation collected clinical data [Ritchie articular index, Health Assessment Questionnaire (HAQ) index, extra‐articular manifestations] and blood for biological analyses [C‐reactive protein (CRP), rheumatoid factor, ANCA, aCLA, aβ2‐GP1A]. ANCA were detected by indirect immunofluorescence on neutrophils and their specificity was determined by enzyme‐linked immunosorbent assay (ELISA) and confirmed by immunoblotting; aCLA and aβ2‐GP1A were detected by ELISA. Results. Patients had mild RA (Ritchie = 11/78 ± 9.6; HAQ = 0.79/3 ± 0.7), probably due to the recruitment procedure. ANCA, aCLA and aβ2‐GP1A frequencies were 18.5, 7 and 0%, respectively. Titres of ANCA and aCLA were low. A perinuclear ANCA staining pattern was exclusively observed and lactoferrin was shown to be the major antigen recognized. No relationship was found between ANCA and aCLA and/or rheumatoid factor, or any clinical manifestations. ANCA were more common in RA of longer duration (cut‐off: 4 yr; P = 0.05) and aCLA were correlated with the CRP level (P = 0.05). Conclusions. In RA of recent onset, ANCA and aCLA were detected at low titres and frequencies, and were not associated with any clinical manifestations. A longitudinal study is needed to determine whether their early appearance is predictive of subsequent disease severity.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Rouen</li></settlement></list><tree><noCountry><name sortKey="Bichon Auvel, I" sort="Bichon Auvel, I" uniqKey="Bichon Auvel I" first="I." last="Bichon-Tauvel">I. Bichon-Tauvel</name><name sortKey="Daragon, A" sort="Daragon, A" uniqKey="Daragon A" first="A." last="Daragon">A. Daragon</name><name sortKey="Gilbert, D" sort="Gilbert, D" uniqKey="Gilbert D" first="D." last="Gilbert">D. Gilbert</name><name sortKey="Jouen Eades, F" sort="Jouen Eades, F" uniqKey="Jouen Eades F" first="F." last="Jouen-Beades">F. Jouen-Beades</name><name sortKey="Krzanowska, K" sort="Krzanowska, K" uniqKey="Krzanowska K" first="K." last="Krzanowska">K. Krzanowska</name><name sortKey="Le Loe T, X" sort="Le Loe T, X" uniqKey="Le Loe T X" first="X." last="Le Loe T">X. Le Loe T</name><name sortKey="Tron, F" sort="Tron, F" uniqKey="Tron F" first="F." last="Tron">F. Tron</name><name sortKey="Vittecoq, O" sort="Vittecoq, O" uniqKey="Vittecoq O" first="O." last="Vittecoq">O. Vittecoq</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Menard, J F" sort="Menard, J F" uniqKey="Menard J" first="J. F." last="Menard">J. F. Menard</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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